Mesalazine Improves Replication Fidelity in Cultured Colorectal Cells
نویسندگان
چکیده
منابع مشابه
Mesalazine improves replication fidelity in cultured colorectal cells.
Epidemiologic studies indicate that mesalazine has chemopreventive effects in inflammatory bowel disease-associated colorectal cancer. Most of our general understanding of chemoprevention in colorectal cancer is, however, derived from aspirin, which is structurally similar to mesalazine. Herein we determined the influence of aspirin and mesalazine on replication fidelity in cultured colorectal ...
متن کاملConditioned Medium from Cultured Colorectal Cancer Cells Affects Peripheral Blood Mononuclear Cells Inflammatory Phenotype in Vitro
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Studies have indicated that immune cells and soluble factors play a key role in maintaining the balance between tumor-promoting inflammation and anti-tumor immunity. It has been shown that secreted cytokines from CRC cell lines could affect peripheral blood mononuclear cells (PBMCs), monocytes, and macrophages phenot...
متن کاملThe nucleotide composition of microsatellites impacts both replication fidelity and mismatch repair in human colorectal cells
Microsatellite instability is a key mechanism of colon carcinogenesis. We have previously studied mutations within a (CA)13 microsatellite using an enhanced green fluorescent protein (EGFP)-based reporter assay that allows the distinction of replication errors and mismatch repair (MMR) activity. Here we utilize this assay to compare mutations of mono- and dinucleotide repeats in human colorecta...
متن کاملReplication stress in colorectal cancer stem cells
Mounting evidence indicates that human neoplasms are dynamic, heterogeneous and hierarchical systems maintained by subpopulations of immature, selfrenewable and multipotent cells known as cancer stem cells (CSCs). CSCs are considered (1) drivers of tumor initiation, progression and spreading; (2) promoters of chemotherapeutic resistance; and (3) seeds for tumor relapse [1]. Further underscoring...
متن کامل[DNA replication fidelity].
DNA replication fidelity plays fundamental role in faithful transmission of genetic material during cell division and during transfer of genetic material from parents to progeny. Replicative polymerases are the main guardian responsible for high replication fidelity of genomic DNA. DNA main replicative polymerases are also involved in many DNA repair processes. High fidelity of DNA replication ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2005
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-04-3824